Current state‐of‐the‐art hyperpolarized 13C‐acetate‐to‐acetylcarnitine imaging is not indicative of the altered balance between glucose and fatty acid utilization associated with diabetes
نویسندگان
چکیده
1 Institute of Medical Engineering, Technische Universit at Munchen, Munich, Germany 2 Department of Clinical Medicine, Aarhus University, Aarhus, Denmark 3 Department of Endocrinology and Internal medicine, Aarhus University Hospital, Aarhus, Denmark 4 Danish Diabetes Academy, Aarhus, Denmark 5 Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universit€at M€ unchen, Munich, Germany 6 GE Global Research, Munich, Germany E-mail: [email protected]
منابع مشابه
Investigation of metabolic changes in STZ-induced diabetic rats with hyperpolarized [1-13C]acetate
In the metabolism of acetate several enzymes are involved, which play an important role in free fatty acid oxidation. Fatty acid metabolism is altered in diabetes patients and therefore acetate might serve as a marker for pathological changes in the fuel selection of cells, as these changes occur in diabetes patients. Acetylcarnitine is a metabolic product of acetate, which enables its transpor...
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INTRODUCTION: Acetylcarnitine is a necessary intermediate in the mitochondrial oxidation of acetate, since it transports the acetyl moiety across the mitochondrial membrane [1]. It has only been observed using hyperpolarized methods [2,3] or with localized polarization transfer sequences [5]. Glutamate has been used as an indicator of citric acid cycle (TCA) fluxes following [2-C]acetate infusi...
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1. The extractions of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo were calculated from measurements of their arterial and coronary sinus blood concentration. Elevation of plasma free fatty acid concentrations by infusion of intralipid and heparin resulted in increased extraction of free fatty acids and diminished extractions of glucose, lactate and pyruvate by the heart...
متن کاملIn vivo enzymatic activity of acetylCoA synthetase in skeletal muscle revealed by (13)C turnover from hyperpolarized [1-(13)C]acetate to [1-(13)C]acetylcarnitine.
BACKGROUND Acetate metabolism in skeletal muscle is regulated by acetylCoA synthetase (ACS). The main function of ACS is to provide cells with acetylCoA, a key molecule for numerous metabolic pathways including fatty acid and cholesterol synthesis and the Krebs cycle. METHODS Hyperpolarized [1-(13)C]acetate prepared via dissolution dynamic nuclear polarization was injected intravenously at di...
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